Featured Publications

Secretory MPP3 reinforce myeloid differentiation trajectory and amplify myeloid cell production.
Kang YA, Paik HJ, Zhang SY, Chen J, Olson OC, Mitchell CA, Collins A, Swann JW, Warr M, Fan R, and Passegué E
J Exp Med . 2023 Aug 7;220(8):e20230088

Aged Hematopoietic Stem Cells Are Refractory to Bloodborne Systemic Rejuvenation Interventions
Ho TT, Dellorusso PV, Verovskaya EV, Bakker ST, Flach J, Smith LK, Ventura PB, Lansinger OM, Herault A, Zhang SY, Kang YA, Mitchell CA, Villeda SA, Passegue E
J Exp Med 2021 Jul 5;218(7):e20210223

Deregulated Notch and Wnt Signaling Activates Early-Stage Myeloid Regeneration Pathways in Leukemia
Kang YA, Pietras EM, Passegue E
J Exp Med 2020 Mar 2;217(3):e20190787

Normal Hematopoiesis Is a Balancing Act of Self-Renewal and Regeneration
Olson OC*, Kang YA*, Passegue E (*Equal contribution)
Cold Spring Harb Perspect Med 2020 Dec 1;10(12):a035519

Myeloid Progenitor Cluster Formation Drives Emergency and Leukaemic Myelopoiesis
Herault A, Binnewies M, Leong S, Calero-Nieto FJ, Zhang SY, Kang YA, Wang X, Pietras EM, Chu SH, Barry-Holson K, Armstrong S, Gottgens B, Passegue E
Nature 2017 Apr 6;544(7648):53-58

Exosome Complex Orchestrates Developmental Signaling to Balance Proliferation and Differentiation During Erythropoiesis
McIver SC, Katsumura KR, Davids E, Liu P, Kang YA, Yang D, Bresnick EH
Elife 2016 Aug 20;5:e17877

Hematopoietic Signaling Mechanism Revealed From a Stem/Progenitor Cell Cistrome
Hewitt KJ, Kim DH, Devadas P, Prathibha R, Zuo C, Sanalkumar R, Johnson KD, Kang YA, Kim JS, Dewey CN, Keles S, Bresnick EH
Mol Cell 2015 Jul 2;59(1):62-74

Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerative Conditions
Pietras EM, Reynaud D, Kang YA, Carlin D, Calero-Nieto FJ, Leavitt AD, Stuart JM, Gottgens B, Passegue E
Cell Stem Cell 2015 Jul 2;17(1):35-46

The Exosome Complex Establishes a Barricade to Erythroid Maturation
McIver SC*, Kang YA*, DeVilbiss AW, O’Driscoll CA, Ouellette JN, Pope NJ, Camprecios G, Chang CJ, Yang D, Bouhassira EE, Ghaffari S, Bresnick EH (*Equal contribution)
Blood 2014 Oct 2;124(14):2285-97

Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy
Klionsky DJ and 1269 authors including Kang YA
Autophagy 2012 Apr;8(4):445-544

Autophagy Driven by a Master Regulator of Hematopoiesis
Kang YA, Sanalkumar R, O’Geen H, Linnemann AK, Chang CJ, Bouhassira EE, Farnham PJ, Keles S, Bresnick EH
Mol Cell Biol 2012 Jan;32(1):226-39

Discovering Hematopoietic Mechanisms Through Genome-Wide Analysis of GATA Factor Chromatin Occupancy
Fujiwara T, O’Geen H, Keles S, Blahnik K, Linnemann AK, Kang YA, Choi K, Farnham PJ, Bresnick EH
Mol Cell 2009 Nov 25;36(4):667-81

Short Hairpin RNA-Expressing Oncolytic Adenovirus-Mediated Inhibition of IL-8: Effects on Antiangiogenesis and Tumor Growth Inhibition
Yoo JY, Kim JH, Kim J, Huang JH, Zhang SN, Kang YA, Kim H, Yun CO
Gene Ther 2008 May;15(9):635-51

Novel Cancer Antiangiotherapy Using the VEGF Promoter-Targeted Artificial Zinc-Finger Protein And Oncolytic Adenovirus
Kang YA*, Shin HC*, Yoo JY, Kim JH, Kim JS, Yun CO (*Equal contribution)
Mol Ther 2008 Jun;16(6):1033-40

Transduction of Artificial Transcriptional Regulatory Proteins Into Human Cells
Yun CO, Shin HC, Kim TD, Yoon WH, Kang YA, Kwon HS, Kim SK, Kim JS
Nucleic Acids Res 2008 Sep;36(16):e103